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ChemicalBook CAS DataBase List NOR-BETA-CIT

NOR-BETA-CIT synthesis

7synthesis methods
CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC

135416-43-2
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NOR-BETA-CIT

136794-87-1
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Yield:136794-87-1 75%

Reaction Conditions:

Stage #1: (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterwith carbonochloridic acid 1-chloro-ethyl ester in dichloromethane;Heating;
Stage #2: with methanolHeating;

References:

Tamagnan, Gilles;Alagille, David;Fu, Xing;Kula, Nora S.;Baldessarini, Ross J.;Innis, Robert B.;Baldwin, Ronald M. [Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,# 4,p. 1131 - 1133]

50373-10-9 Synthesis
(1R)-TROP-2-ENE-2-CARBOXYLIC ACID METHYL ESTER

50373-10-9
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NOR-BETA-CIT

136794-87-1
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