NSC 31150 synthesis

Yield:51244-45-2 96%

Reaction Conditions:

with SO₃H and COOH functionalized pine-cone derived carbon nanoparticles in water at 25; for 0.116667 h;Green chemistry;Knoevenagel Condensation;

Steps:

3.5. General Procedure for the Synthesis of 5-arylidene-2,4-thiazolidinedione Derivatives (4a-j)

General procedure: Knovenagel condensation of aromatic aldehyde (1mmol) and 2,4-thiazolidinedione (1 mmol) was performedin the presence of Pine -SO3H NPs (0.05 g) and water (5mL) as a solvent. The mixture was stirred at room temperature.Upon completion of the reaction, monitored by TLC(ethyl acetate: n-hexane 3:7), the mixture filtered off. Theproducts were purified by recrystallization from EtOH.

References:

Ghorbani, Fatemeh;Pourmousavi, Seied Ali;Kiyani, Hamzeh [Letters in Organic Chemistry,2021,vol. 18,# 1,p. 66 - 81]