ChemicalBook CAS DataBase List NSC42124

NSC42124 synthesis

4synthesis methods

Product Name:NSC42124
CAS Number:6633-62-1
Molecular formula:C16H10ClNO2
Molecular Weight:283.71

100-52-7 Synthesis

100-52-7
944 suppliers
$21.30/2g

106-47-8 Synthesis

106-47-8
466 suppliers
$5.00/5G

127-17-3 Synthesis

127-17-3
515 suppliers
$5.00/10g

6633-62-1
22 suppliers
$75.00/500mg

Yield:6633-62-1 79%

Reaction Conditions:

Stage #1: benzaldehyde;4-chloro-anilinewith borane-THF in acetonitrile at 65; for 0.166667 h;
Stage #2: 2-oxo-propionic acid in acetonitrile; for 24 h;

Steps:

A5 Example A5
Production of 6-chloro-2-phenylquinoline-4-carboxylic acid

To a solution of 4-chloroaniline (1.30 g, 10.2 mmol) in acetonitrile (9.5 mL), benzaldehyde (1.21 g, 11.4 mmol) and boron trifluoride-tetrahydrofuran complex (313 μL, 2.84 mmol) were added, and the mixture was heated to 65° C. 10 minutes later, a solution of pyruvic acid (0.500 g, 5.68 mmol) in acetonitrile (5.7 mL) was added dropwise thereto over 3 hours. 21 hours later, the reaction solution was cooled to room temperature, and saturated aqueous sodium chloride solution was added thereto, followed by extraction with tetrahydrofuran.
The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then filtered, and the solvent was distilled off under reduced pressure.
The obtained residue was suspended and washed in chloroform and dried under reduced pressure to obtain the title compound (1.27 g, yield: 79%) as an ocher solid.
¹H-NMR (400 MHz, DMSO-D₆) δ: 14.1 (1H, s), 8.79 (1H, d, J=2.4 Hz), 8.56 (1H, s), 8.32-8.28 (2H, m), 8.19 (1H, d, J=9.2 Hz), 7.89 (1H, dd, J=9.2, 2.4 Hz), 7.60-7.55 (3H, m)
ESI-MS (m/z): 284, 286 (M+H)⁺

References:

US2022/169640,2022,A1 Location in patent:Paragraph 0152-0154

17630-76-1 Synthesis