ChemicalBook CAS DataBase List NSC44969

NSC44969 synthesis

13synthesis methods

Product Name:NSC44969
CAS Number:73006-78-7
Molecular formula:C12H10ClN
Molecular Weight:203.67

63069-48-7
233 suppliers
$15.00/10g

98-80-6 Synthesis

98-80-6
722 suppliers
$5.00/5g

73006-78-7
57 suppliers
$71.00/100mg

Yield:73006-78-7 90%

Reaction Conditions:

with bis-triphenylphosphine-palladium(II) chloride;potassium carbonate in 1,2-dimethoxyethane;water; for 16 h;Reflux;

Steps:

1

4-chloro-2-iodoaniline (90 g, 355 mmol), phenylboronic acid (52.0 g, 426 mmol), potassium carbonate (147 g, 1065 mmol), DME (720 ml) and water (720 ml) were added to a 5 L flask. After degassing, bis(triphenylphosphine)palladium(II) chloride (4.98 g, 7.10 mmol) was added to the mixture and refluxed for 14 hours. After completion, the reaction mixture was diluted with EtOAc (1 L).And separate the two layers. The aqueous layer was extracted with EtOAc (EtOAc m.The resulting oil was purified by column chromatography using EtOAc /hexanes.5-Chloro-[1,1'-biphenyl]-2-amine (90% yield) was obtained.

References:

CN110128479,2019,A Location in patent:Paragraph 0323; 0324

873-38-1 Synthesis