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Nsc92153 synthesis

4synthesis methods
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Yield:19522-39-5 52.5%

Reaction Conditions:

Stage #1: N-benzyloxycarbonyl-D-glutamic acidwith dicyclohexyl-carbodiimide in tetrahydrofuran; for 7 h;cooling;
Stage #2: with ammonia in tetrahydrofuran; for 0.5 h;cooling;

References:

Yang, Hong-Zhen;Xu, Song;Liao, Xue-Yan;Zhang, Suo-De;Liang, Zheng-Lun;Liu, Bai-He;Bai, Jin-Ye;Jiang, Chao;Ding, Jian;Cheng, Gui-Fang;Liu, Gang [Journal of Medicinal Chemistry,2005,vol. 48,# 16,p. 5112 - 5122]