ChemicalBook CAS DataBase List Buparlisib Hydrochloride

Buparlisib Hydrochloride synthesis

3synthesis methods

Product Name:Buparlisib Hydrochloride
CAS Number:1312445-63-8
Molecular formula:C18H22ClF3N6O2
Molecular Weight:446.86

4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine

10244-24-3
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$65.00/50mg

1312445-63-8
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 2 h / 84 °C / Inert atmosphere
2: caesium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 0.75 h / 45 °C / Inert atmosphere
3: hydrogenchloride / isopropyl alcohol; acetone / 2.25 h / Inert atmosphere

References:

WO2012/44727,2012,A2

106447-97-6 Synthesis

106447-97-6
345 suppliers
$11.00/1g

1312445-63-8
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References

944401-56-3 Synthesis

2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE

944401-56-3
157 suppliers
$32.00/250mg

4,4'-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine-2,4-diyl)diMorpholine

1370351-45-3
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1312445-63-8
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References

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