ChemicalBook CAS DataBase List o-fluorocinnamic acid

o-fluorocinnamic acid synthesis

9synthesis methods

Product Name:o-fluorocinnamic acid
CAS Number:18944-77-9
Molecular formula:C9H7FO2
Molecular Weight:166.15

348-52-7 Synthesis

348-52-7
295 suppliers
$6.00/5g

79-10-7 Synthesis

79-10-7
688 suppliers
$20.16/100 mL

18944-77-9
27 suppliers
$12.00/5g

Yield:18944-77-9 87%

Reaction Conditions:

with triethylamine in water at 100; for 12 h;Heck Reaction;

Steps:

General procedure: In a typical Heck coupling reaction between iodobenzene and acrylic acid, 10 mmol of iodobenzene and 30 mmol of acrylic acid were mixed with 50 mmol of triethylamine and 10 mL of distill water. The insoluble PdIPN catalyst (2.3 g) was added to the solution, and the reactants were heated in an oil bath at 100 °C for 12 h under stirring. After the reaction, the catalysts were filtered, thoroughly washed with water and ethanol (at least three times) and dried in the air for the next round of use. The white product was precipitated out by adding 1 mol/L HCl solution, then separated by centrifugation and filtration, washed repeatedly with cold water, and dried in vacuum for 6 h. The yield from the reaction between iodobenzene and acrylic acid was 87percent.

References:

Zhan, Kan;Lu, Ping;Dong, Jian;Hou, Xu [Chinese Chemical Letters,2020,vol. 31,# 6,p. 1630 - 1634] Location in patent:supporting information

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141-82-2 Synthesis