OCTAHYDROQUINOLINE-4(1H)-ONE synthesis
- Product Name:OCTAHYDROQUINOLINE-4(1H)-ONE
- CAS Number:58869-89-9
- Molecular formula:C9H15NO
- Molecular Weight:153.22
54924-14-0
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58869-89-9
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$60.00/100mg
Yield:58869-89-9 98%
Reaction Conditions:
with ammonia;water in 1,4-dioxane at 120; for 16 h;
Steps:
l-Cyclohex-l-en-l-yl-3-(dimethylamino)propan-l-one (17.9 g, 99 mmol) was combined with 1 ,4-dioxane (40 mL) and concentrated NH4OH (40 mL) in a stainless steel pressure vessel. The vessel was sealed then heated in an oil bath at 120 0C. After 16 hr the mixture was cooled to RT and concentrated. The residue was taken up in CH2Cl2, dried (MgSO4), filtered, and concentrated to give octahydroquinolin-4(lH)-one as an amber oil (14.77 g, 98%). The crude material was used immediately in the next step without purification.
References:
WO2008/88744,2008,A1 Location in patent:Page/Page column 39