ChemicalBook CAS DataBase List olivetolic acid

olivetolic acid synthesis

12synthesis methods

Product Name:olivetolic acid
CAS Number:491-72-5
Molecular formula:C12H16O4
Molecular Weight:224.25

Benzoic acid, 2-pentyl-4,6-bis(phenylmethoxy)-

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Yield:491-72-5 88%

Reaction Conditions:

with palladium on activated charcoal;hydrogen in ethyl acetate; for 18 h;

Steps:

5.3 Step 3:

To a round-bottom flask containing Pd/C (312 mg, 2.93 mmol) was added EtOAc (5 mL). To this mixture was added a solution of 2,4-dibenzyloxy-6-pentyl-benzoic acid (625 mg, 1.55 mmol) in EtOAc (10 mL). The flask was backfilled with nitrogen and stirred under a hydrogen balloon for 18 h. The mixture was filtered through celite and the filtrate was concentrated to give 2,4-dihydroxy-6-pentyl-benzoic acid (305 mg, 1.36 mmol, 88%).

References:

WO2021/54,2021,A1 Location in patent:Paragraph 0139