OTAVA-BB BB7011460335 synthesis
- Product Name:OTAVA-BB BB7011460335
- CAS Number:383-23-3
- Molecular formula:C10H12FNO3S
- Molecular Weight:245.27
Yield:383-23-3 81%
Reaction Conditions:
with iodine pentoxide in acetonitrile at 20 - 60; for 12 h;
Steps:
8 Example 8:
At room temperature, p-fluorothiophenol (1.25 ml, 10 mmol) was added sequentially to a 50 mL round bottom flask,Morpholine (1.75 ml, 20 mmol), acetonitrile (20 mL) and diiodide pentoxide (10 mmol).Then, the reaction mixture was stirred at 60 ° C for 12 hours (TLC detection reaction).Then, the reaction was stopped and concentrated under reduced pressure to obtain a crude product. Finally with petroleum ether andEthyl acetate in a mixture of eluent, and flash column chromatography (silica gel column)To give the corresponding product sulfonamide compound (1.99 g as a white solid, 81% yield).
References:
CN107033106,2017,A Location in patent:Paragraph 0024; 0025
