OXALYL MONOGUANYLHYDRAZIDE synthesis
- Product Name:OXALYL MONOGUANYLHYDRAZIDE
- CAS Number:89797-67-1
- Molecular formula:C3H6N4O3
- Molecular Weight:146.1
2582-30-1
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Yield:89797-67-1 19%
Reaction Conditions:
with pyridine at 20; for 12 h;
Steps:
7.1 2-(2-Carbamimidoylhydrazinyl)-2-oxoacetic acid
To a solution of 1-aminoguanidine carbonic acid salt (12 g, 88 mmol) in pyridine (50 ml) was added ethyl 2-chloro-2-oxoacetate (10 g, 73.24 mmol). The resulting solution was stirred for 12 h at room temperature. The resulting solution was diluted with PE (200 ml). The solids were collected by filtration and then dissolved in water (50 ml), the pH was adjusted to 8 with NaOH (aq., 10N). The product precipitated and was filtered to afford ethyl 2-(2-carbamimidoylhydrazinyl)-2- oxoacetic acid as a white solid (2 g, 19%). LC/MS (ES, m/z): [M+H]+ 147.0
References:
WO2014/66743,2014,A1 Location in patent:Paragraph 0146
