![](/CAS/GIF/23135-22-0.gif)
Oxamyl synthesis
- Product Name:Oxamyl
- CAS Number:23135-22-0
- Molecular formula:C7H13N3O3S
- Molecular Weight:219.26
Yield:-
Reaction Conditions:
with triethylamine in water at 42;Inert atmosphere;
Steps:
1
Example1:PreparationofamorphousoxamylinaccordancewiththedisclosureofUSPAT.NO.5,284,962,Example2Atwo-stage,co-currentlyfed,continuousreactorsystemwasusedtoreactMIC(methylisocyanate)andtheoxime,methyl2-(dimethylamino)-N-hydroxy-2-oxoethanimidothioate,toproducemethyl2-(dimethylamino)-N-[[(methylamino)carbonyl]oxy]-2-oxoethanimidothioate(oxamyl).Thereactorsweremaintainedatapproximately42.Duringsteadystateoperation,methylisocyanate(MIC)wasfedatarateof1.2g/minandvaporizedandmixedwithnitrogenwhichwasfedatapproximately2200mL/min.Theoximewasfedatarateof7.9g/minasa40slurryinwatercontaining0.2TEA.Conversionoftheoximeinthefirstreactorwasabout93.Thecompositionoftheproductsolutionfromthesecondreactorwasapproximately47titleproduct,0.9oximeand0.8DMU(dimethylurea).Thiscompositioncorrespondedto97conversionoftheoximeand8oftheoriginalMICasDMU.Theventstreamfromthesecondreactorcontainedabout0.2MICcorrespondingtoremovalofgreaterthan99fromthegasstream.AsshowninFigure4,theX-raypowderdiffractionpatternoftheresultingoxamylproducthasnosignificantsignals,whichindicatestheoxamylproductpreparedinaccordancewiththedisclosureofUSPAT.NO.5,284,962isamorphous.
References:
JIANGSU ROTAM CHEMISTRY CO., LTD.;BRISTOW, James, Timothy WO2018/99203, 2018, A1 Location in patent:Page/Page column 14-15