OXAZOLO[4,5-B]PYRIDIN-2-AMINE synthesis
- Product Name:OXAZOLO[4,5-B]PYRIDIN-2-AMINE
- CAS Number:40926-66-7
- Molecular formula:C6H5N3O
- Molecular Weight:135.12
16867-03-1
556 suppliers
$10.00/25g
506-68-3
147 suppliers
$10.00/1g
40926-66-7
35 suppliers
$175.00/500mg
Yield:40926-66-7 80%
Reaction Conditions:
in water; for 0.25 h;Reflux;
Steps:
18.1 3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-N-oxazolo[4,5-b]pyridin-2-yl-propionamide
Step 1: To a solution of cyanogen bromide (4.5 g, 42 mmol) in H2O (18 mL) was added 2-amino-3-hydroxypyridine (4.5 g, 40.9 mmol) and the resultant reaction mixture was stirred at reflux temperature 15 minutes and then cooled to room temperature. The reaction mixture was neutralized carefully with solid NaHCO3 and diluted with water. The solid was collected, washed 5 times with H2O and dried at 50° C. under vacuum to afford oxazolo[4,5-b]pyridin-2-ylamine (4.42 g, 80%): 1H NMR (300 MHz, DMSO-d6) δ ppm 6.95 (dd, J=7.82, 5.18 Hz, 1H) 7.65 (dd, J=7.82, 1.41 Hz, 1H) 7.91 (s, 2H) 8.08 (dd, J=5.18, 1.41 Hz, 1H).
References:
US2012/149718,2012,A1 Location in patent:Page/Page column 34
16867-03-1
556 suppliers
$10.00/25g
104619-51-4
96 suppliers
$12.00/100mg
40926-66-7
35 suppliers
$175.00/500mg