OXO-PIPERIDIN-1-YL-ACETIC ACID synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / tetrahydrofuran / 0 °C / Inert atmosphere
2.2: pH 1 / Inert atmosphere

References:

Robinson, Colin W.;Rye, Carl S.;Chessum, Nicola E. A.;Jones, Keith [Organic and Biomolecular Chemistry,2015,vol. 13,# 27,p. 7402 - 7407] Robinson, Colin W.;Rye, Carl S.;Chessum, Nicola E. A.;Jones, Keith [Organic and Biomolecular Chemistry,2015,vol. 13,# 27,p. 7402 - 7407]