ChemicalBook CAS DataBase List p-Tolyl isocyanate

p-Tolyl isocyanate synthesis

13synthesis methods

Product Name:p-Tolyl isocyanate
CAS Number:622-58-2
Molecular formula:C8H7NO
Molecular Weight:133.15

32315-10-9 Synthesis

32315-10-9
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$10.00/1g

106-49-0
390 suppliers
$5.00/5 g

622-58-2
179 suppliers
$5.00/5g

Yield:622-58-2 90%

Reaction Conditions:

in chloroform at 20; for 2 h;Cooling with ice;

Steps:

General methods for aryl isocyanate (2a-h)
General procedure: To a solution of bis(trichloromethyl) carbonate in CHCl3 was added dropwisearomatic amines in CHCl3 in an ice bath. When the addition was finished, thereaction mixture was stirred at room temperature for 1-8 h and then heated atreflux until the reaction solution clarified. After the solvent was evaporatedunder atmospheric pressure, the residual liquid could be evaporated underreduced pressure.

References:

Zheng, Zhonghui;Du, Deping;Cao, Lili;Liu, Jun;Chen, Xiaofang [Journal of Antibiotics,2016,vol. 69,# 11,p. 811 - 817]

FullText

99-94-5 Synthesis