Palmitoylethanolamide synthesis
- Product Name:Palmitoylethanolamide
- CAS Number:544-31-0
- Molecular formula:C18H37NO2
- Molecular Weight:299.49
Yield:544-31-0 98.2%
Reaction Conditions:
Stage #1: 1-hexadecylcarboxylic acid in water at 100; for 2 h;
Stage #2: ethanolamine in water at 100 - 200; for 22 h;
Steps:
Add 1280Kg of the obtained high-purity compound palmitic acid A into the reactor, add 1280Kg of deionized water, and under stirring, uniformly raise the temperature to 100°C within 1 hour, keep the temperature stable for 1 hour, and then gradually add the high-purity compound to the reactor. The compound palmitic acid A is 1.0-1.2 times, preferably 1.06 times the number of moles of monoethanolamine solution, control the dropping rate, add all the monoethanolamine solution dropwise within 2 hours, then increase the temperature and control the acylation reaction temperature at 150200 , preferably 155165, stir for 20 hours, after the acylation reaction is completed, keep it at 100115 for 0.5-1.5 hours, preferably 1 hour, remove the bottom water phase, and quickly remove the upper layer of the reaction liquid. Centrifugation and cooling until a flaky solid is precipitated and dried to obtain about 1470Kg of flaky hexadecyl amide ethanol (PEA);The compound A palmitic acid obtained from the hydrolysis reaction and rectification of this scheme,The purity can reach more than 99.5%. This makes the yield in the acylation reaction up to 98.2%, and the purity of the final product, hexadecyl amide ethanol (PEA), can reach more than 99%.
References:
CN112778119,2021,A Location in patent:Paragraph 0033
