Phenol, 2-amino-5-fluoro-4-methyl- (9CI) synthesis

Yield:83341-37-1 88%

Reaction Conditions:

with hydrogen at 25; under 75007.5 Torr;

Steps:

22

5-Fluoro-4-methyl-2-nitrophenol (D21 , 162 mg, 0.946 mmol) was reduced using H-Cube hydrogenator (full H₂ mode, 25 ⁰C, 1 ml_/min). The reaction was concentrated by rotary evaporation to give 2-amino-5-fluoro-4-methylphenol (D22, 117 mg, 88 % yield) as a pale yellow solid.¹H NMR δ (CDCI₃, 400 MHz) 2.13 (3 H, s), 6.51 (1 H, d, J 10), 6.61 (1 H, d, J 7.6).

References:

WO2009/37294,2009,A1 Location in patent:Page/Page column 74