Phenol, 2-nitro-4-(1-pyrrolidinylsulfonyl)- synthesis

3synthesis methods

Product Name:Phenol, 2-nitro-4-(1-pyrrolidinylsulfonyl)-
CAS Number:722464-31-5
Molecular formula:C10H12N2O5S
Molecular Weight:272.28

1-[(4-methoxy-3-nitrophenyl)sulfonyl]pyrrolidine

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Phenol, 2-nitro-4-(1-pyrrolidinylsulfonyl)-

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Yield:-

Reaction Conditions:

Stage #1: 1-(4-methoxy-3-nitrobenzenesulfonyl)pyrrolidinewith potassium hydroxide;water in dimethyl sulfoxide at 0 - 80; for 6 h;
Stage #2: with hydrogenchloride in water;dimethyl sulfoxide;

Steps:

33.3 Production of 1-(4-methoxy-3-nitrobenzenesulfonyl)pyrrolidine

Step 3 Production of 2-nitro-4-(pyrrolidine-1-sulfonyl)phenol 1-(4-Methoxy-3-nitrobenzenesulfonyl)pyrrolidine (2.054 g) was dissolved in dimethyl sulfoxide (40 mL), and 50% aqueous potassium hydroxide (40 mL) was added under ice-cooling. After stirring with heating at 80° C. for 6 hrs, the mixture was ice-cooled, and 6N hydrochloric acid (80 mL) was added. The mixture was extracted with chloroform. The extract was washed successively with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (2.198 g) as a yellow solid.

References:

US2007/10670,2007,A1 Location in patent:Page/Page column 91

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References

22117-79-9 Synthesis

4-methoxy-3-nitrobenzenesulphonyl chloride

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References