Α-PHENYLCINNAMONITRILE synthesis

9synthesis methods

Product Name:Α-PHENYLCINNAMONITRILE
CAS Number:16610-80-3
Molecular formula:C15H11N
Molecular Weight:205.25

7677-24-9 Synthesis

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Yield:16610-80-3 98%

Reaction Conditions:

with tetrakis-(triphenylphosphine)-palladium;1,3-bis-(diphenylphosphino)propane;2,2-Dimethylpropanoic anhydride in cyclohexane at 160; for 12 h;

Steps:

12 Preparation Example 12

In a 10 mL reaction tube, add 0.2 mmol of α-phenylcinnamic acid, 0.3 mmol of trimethylsilyl cyanide, 5 mol% of tetrakistriphenylphosphine palladium,1,3-bis(diphenylphosphine)propane 10 mol%, trimethylacetic anhydride 120 mol%, cyclohexane as solvent, react at 160 for 12 h.After the reaction, the target compound aryl nitrile compound (Ar=α-phenylcinnamyl) was obtained through column chromatography separation to obtain a white solid with a yield of 98%.

References:

CN114524751,2022,A Location in patent:Paragraph 0022