PHENYLTHIOHYDANTOIN TRYPTOPHAN) synthesis
- Product Name:PHENYLTHIOHYDANTOIN TRYPTOPHAN)
- CAS Number:29635-97-0
- Molecular formula:C18H15N3OS
- Molecular Weight:321.4
103-72-0
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Yield:29635-97-0 83%
Reaction Conditions:
with dmap;triethylamine in dichloromethane at 40;
Steps:
4.37 4.1.32. Synthesis of (S)-5-((1H-indol-3-yl)methyl)-3-isopropyl-2-thioxoimidazolidin-2,4-dione (28)
General procedure: A mixture of (S)-methyl 2-amino-3-(1H-indol-3-yl)propanoate(0.60 g, 2.75 mmol), NEt3 (0.3 mL), isopropyl isothiocyanates(0.34 g, 3.3 mmol) in dichloromethane (40 mL) were stirred at40 C overnight. The mixture was concentrated in vacuum whenthe reaction was complete detected by TLC, and the crude productwas chromatographed on silica gel (petroleum oil/ethyl acetate30:1) to give compound 23 (0.63 g) as yellow solid in 85% yield
References:
Huang, Yuanqiong;Liu, Yongxian;Liu, Yuxiu;Song, Hongjian;Wang, Qingmin [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 3,p. 462 - 473]
73-22-3
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