ChemicalBook CAS DataBase List Piperidine, 4-(1H-pyrazol-1-yl)- (9CI)

Piperidine, 4-(1H-pyrazol-1-yl)- (9CI) synthesis

5synthesis methods

Product Name:Piperidine, 4-(1H-pyrazol-1-yl)- (9CI)
CAS Number:762240-09-5
Molecular formula:C8H13N3
Molecular Weight:151.21

1269429-29-9 Synthesis

tert-butyl 4-(1H-pyrazol-1-yl)piperidine-1-carboxylate

1269429-29-9
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762240-09-5
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Yield: 96%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 20; for 1 h;

Steps:

Step C: 4-(1H-pyrazol-1-yl)piperidine (i-4)
Step C: 4-(1H-pyrazol-1-yl)piperidine (i-4) (0094) The title compound from Step B above (50 mg, 0.2 mmol) was dissolved in 4 M HCl in dioxane (2.0 mL) and stirred at RT for 1 h. The product was concentrated under reduced pressure and dried under high vacuum to give the title compound (i-17) (30 mg, 96%). ESI-MS calculated for C₈H₁₃N₃: Exact Mass: 151.11; Found 152.10.

References:

Merck Sharp & Dohme Corp.;MORRIELLO, Gregori, J.;CHANG, Lehua;EDMONDSON, Scott, D. EP2632457, 2017, B1 Location in patent:Paragraph 0088; 0094