ChemicalBook CAS DataBase List Piracetam

Piracetam synthesis

10synthesis methods

Product Name:Piracetam
CAS Number:7491-74-9
Molecular formula:C6H10N2O2
Molecular Weight:142.16

Prepared by condensing 2-pyrrolidinone with ethyl chloroacetate in the presence of a metal hydride and then converting the ester into an amide with ammonia.

59776-88-4 Synthesis

2-OXO-1-PYRROLIDINEACETIC ACID METHYL ESTER

59776-88-4
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7491-74-9
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Yield:7491-74-9 45.94%

Reaction Conditions:

with ammonia in methanol at 60; for 4 h;

Steps:

69 Synthesis of compound 69.3.

Mixture of compound 69.2 (4.5g, 28.66mmol, 1.0eq) and methanolic ammonia (50ml) was stirred at 60°C for 4h. After completion of reaction, reaction mixture was concentrated under reduced pressure and triturated with diethyl ether to obtain 69.3. (1.87g, Yield: 45.94%). MS(ES): m/z 143.08 [M+H] ⁺.

References:

WO2020/112937,2020,A1 Location in patent:Paragraph 00766-00767

57275-83-9
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7491-74-9
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References

24935-08-8
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$70.00/100mg

7491-74-9
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References

3445-11-2 Synthesis

3445-11-2
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7491-74-9
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References

Butanamide, N-(2-amino-2-oxoethyl)-4-chloro-

64026-51-3
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7491-74-9
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References

Piracetam Related Search:

Trifluoroacetamide N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone Acetamide 2-Cyanoacetamide Thioacetamide Acetaminophen 2-Phenylacetamide N,N-Dimethylacetamide 2-Pyrrolidinone