piro[2.5]octan-6-ol synthesis

2synthesis methods

Product Name:piro[2.5]octan-6-ol
CAS Number:22428-83-7
Molecular formula:C8H14O
Molecular Weight:126.2

13482-22-9 Synthesis

13482-22-9
191 suppliers
$8.00/250mg

22428-83-7
35 suppliers
$695.00/250mg

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 50 °C / Inert atmosphere
2.1: sodium t-butanolate / tetrahydrofuran / 1 h / 20 °C
2.2: 18 h / 20 °C
3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

References:

BIOMARIN PHARMACEUTICAL INC.;WANG, Bing;CHAO, Qi WO2019/133770, 2019, A2

CYCLOHEXANONE, 4-[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]-

130745-59-4
19 suppliers
$133.00/500mg

22428-83-7
35 suppliers
$695.00/250mg

References