ChemicalBook CAS DataBase List Pitavastatin Impurity 29

Pitavastatin Impurity 29 synthesis

7synthesis methods

Product Name:Pitavastatin Impurity 29
CAS Number:148516-15-8
Molecular formula:C25H20FNO2
Molecular Weight:385.43

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol

121660-11-5
222 suppliers
$6.00/100mg

148516-15-8
21 suppliers
inquiry

Yield:-

Steps:

Multi-step reaction with 9 steps
1: tri-n-butylphosphine / pyridine / Ambient temperature
2: 1.) tert-butyllithium / 1.) THF, 2.) THF, -78 deg C, 1 h
3: potassium hydroxide / tetrahydrofuran / 3.5 h / Ambient temperature
4: 100 percent / dimethylsulfoxide / 0.5 h / Ambient temperature
5: 67 percent / palladium(II) chloride, copper(II) chloride, NaOAc / 3 h / 760 Torr / Ambient temperature
6: H₂ / Lindlar cat. / methanol / 25 h / Ambient temperature
7: pyridinium p-toluenesulfonate (PPTS) / toluene / 1.5 h / Heating
8: m-chloroperbenzoic acid (m-CPBA) / CH₂Cl₂ / 1.) -78 deg C, 1 h, 2.) -40 deg C, 30 min
9: calcium carbonate / toluene / 0.5 h / Heating

References:

Takano, Seiichi;Kamikubo, Takashi;Sugihara, Takumichi;Suzuki, Mikio;Ogasawara, Kunio [Tetrahedron Asymmetry,1993,vol. 4,# 2,p. 201 - 204]

Ethyl 2-cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-carboxylate

148516-11-4
101 suppliers
$11.00/1g

148516-15-8
21 suppliers
inquiry

References

148516-12-5
1 suppliers
inquiry

148516-15-8
21 suppliers
inquiry

References

L-erythro-Hexuronic acid, 3,5-dideoxy-4-O-[(1,1-dimethylethyl)dimethylsilyl]-, δ-lactone, 1-hydrate

1068433-24-8
0 suppliers
inquiry

148516-15-8
21 suppliers
inquiry

References

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline

154057-56-4
199 suppliers
$29.00/250mg

148516-15-8
21 suppliers
inquiry

References