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ChemicalBook CAS DataBase List Pivopril
81045-50-3

Pivopril synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: Et3N / CH2Cl2 / 2.5 h / Ambient temperature
2: NH3 / methanol / 0.5 h
3: 95 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature
4: 1.) (CH3)3SiI, 2.) H2O / 1.) CH2Cl2, RT, 1 h, 2.) CH2Cl2, 0 deg C

References:

Suh, John T.;Skiles, Jerry W.;Williams, Bruce E.;Youssefyeh, Raymond D.;Jones, Howard;et al. [Journal of Medicinal Chemistry,1985,vol. 28,# 1,p. 57 - 66]

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