POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE synthesis
- Product Name:POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE
- CAS Number:374564-35-9
- Molecular formula:C6H4BBrF3K
- Molecular Weight:262.9
5467-74-3
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374564-35-9
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Yield:374564-35-9 87%
Reaction Conditions:
with potassium hydrogenfluoride in methanol;water at 0; for 0.5 h;
Steps:
2.1 General Procedure for Preparation of Potassium Organotrifluoroborates (2a-j)
General procedure: To a solution of the appropriate boronic acid, 1a-j (5 mmol) in MeOH (10 mL) was added dropwise a solution of KHF2 (1.56 g, 20 mmol) in H2O (8 mL) using an addition funnel. The mixture was stirred for 30 min and concentrated under high vacuum. The residual solid was extracted with four portions of 20% MeOH in acetone. The combined extracts were concentrated close to the saturation point and Et2O was added until no more precipitation was observed. The solid was collected, washed with two portions of Et2O, and dried under high vacuum to give the corresponding products sufficiently pure for characterization.
References:
Liesen, André P.;Silva, Arisson T.;Sousa, Jokderléa C.;Menezes, Paulo H.;Oliveira, Roberta A. [Tetrahedron Letters,2012,vol. 53,# 32,p. 4240 - 4242] Location in patent:supporting information; experimental part
106-37-6
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374564-35-9
82 suppliers
$7.00/250mg
1256935-40-6
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5467-74-3
450 suppliers
$8.00/1g
374564-35-9
82 suppliers
$7.00/250mg