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77450-05-6

(+)-PPM synthesis

10synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 7 steps
1: 87 percent / Et3N / dioxane; H2O / 15 h / 50 °C
2: 89 percent / pyridine / 1.) 0 deg C, 1 h, 2.) room temperature, 48 h
3: 1.) Et4NOAc*4H2O, 2.) 1 N NaOH / 1.) benzene, reflux, 1.5 h, 2.) MeOH, 0 deg C
4: 45 percent / LiBH4 / tetrahydrofuran
5: 69 percent / pyridine
6: 34 percent / 1.) Na/NH3 (liq.) / tetrahydrofuran
7: 87 percent / CF3COOH

References:

Baker, Gregory L.;Fritschel, Scott J.;Stille, John R.;Stille, John K. [Journal of Organic Chemistry,1981,vol. 46,# 14,p. 2954 - 2960]

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