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ChemicalBook CAS DataBase List Pregabalin Impurity D

Pregabalin Impurity D synthesis

15synthesis methods
31197-66-7 Synthesis
ISOPROPYLPHENYLGLYOXYLATE

31197-66-7
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Yield:53439-96-6 98%

Reaction Conditions:

with C49H76N4O4;aluminum tri-tert-butoxide;yttrium(III) trifluoromethanesulfonate in chloroform;isopropyl alcohol; for 120 h;Molecular sieve;enantioselective reaction;Meerwein-Ponndorf-Verley Reduction;

References:

Wu, Wangbin;Zou, Sijia;Lin, Lili;Ji, Jie;Zhang, Yuheng;Ma, Baiwei;Liu, Xiaohua;Feng, Xiaoming [Chemical Communications,2017,vol. 53,# 22,p. 3232 - 3235] Location in patent:supporting information