propan-2-yl 3-aminopropanoate hydrochloride synthesis
1synthesis methods
- Product Name:propan-2-yl 3-aminopropanoate hydrochloride
- CAS Number:51871-17-1
- Molecular formula:C6H13NO2.HCl
- Molecular Weight:167.63
Yield:51871-17-1 90.2%
Reaction Conditions:
with hydrogenchloride at 20; for 16 h;
Steps:
2.2 Isopropyl 3-aminopropanoate hydrochloride
3-(tert-Butoxycarbonylamino)propanoic acid (100 g, 0.53 mol) was dissolved in 500 mL of 5N HCl in isopropanol. After stirring at RT for 16 h, the reaction mixture was concentrated under reduced pressure. The residue was washed with 200 mL of EA and filtered to give 80 g (90.2%) of the desired compound as a white solid. MS (ESI) m/e [M+1]+ 132.1.
References:
US2015/5277,2015,A1 Location in patent:Paragraph 0202; 0203