Propane,1,3-dichloro-2-(chloroMethoxy)- synthesis

4synthesis methods

Product Name:Propane,1,3-dichloro-2-(chloroMethoxy)-
CAS Number:53883-86-6
Molecular formula:C4H7Cl3O
Molecular Weight:177.46

96-23-1 Synthesis

96-23-1
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53883-86-6
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Yield:53883-86-6 96.1%

Reaction Conditions:

with sodium sulfate;paraformaldehyde in dichloromethane;

Steps:

5.A 5A.

5A. Preparation of Formula (c) A mixture of 1,3-dichloro-2-propanol (10 gm) and paraformaldehyde (3.02 gm) in dichloromethane (100 ml) was cooled to -5° C., and gaseous hydrogen chloride bubbled into the mixture over 25 minutes. The resultant mixture was kept at -8° C. for 14 hours. Sodium sulfate (2 gm) was then added, and the mixture stirred at room temperature for 2 hours. The solid was filtered off, and the filtrate washed with 20% aqueous sodium hydroxide (2*20 ml), and the aqueous phase removed. Solvent was removed from the organic phase under reduced pressure, giving 2-(chloromethoxy)-1,3-dichloropropane as a colorless liquid (13.21 gm, 96.1% yield).

References:

US5565565,1996,A

50-00-0 Synthesis