Propane, 1,3-diisothiocyanato- synthesis
- Product Name:Propane, 1,3-diisothiocyanato-
- CAS Number:52714-52-0
- Molecular formula:C5H6N2S2
- Molecular Weight:158.24
102368-13-8
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Yield:52714-52-0 96.2%
Reaction Conditions:
in dichloromethane;Inert atmosphere;
Steps:
Synthesis of linkers (diisothiocyanate from diamine)
General procedure: To a solution of diamine (0.20 mmol) in dichloromethane (anhydrous, 5 mL), 1,10-Thiocarbonyldi-2(1H)-pyridone (0.22 mmol, 2.2 equiv.) was added and the reaction started with constant stirring in inert atmosphere. The progress of the reaction was monitored by TLC. Flash chromatography (in dichloromethane) afforded the desired product as colorless oil (see Table S1 for % yields).
References:
Kumar, Sunil;Spano, Meredith Newby;Arya, Dev P. [Bioorganic and Medicinal Chemistry,2015,vol. 23,# 13,art. no. 12294,p. 3105 - 3109] Location in patent:supporting information
