Propanimidamide, N-hydroxy-3-(methylamino)- synthesis

Yield:16750-50-8 99.5%

Reaction Conditions:

with hydroxylamine in ethanol;water at 20 - 50; for 27 h;

Steps:

Reaction of 3-methylaminopropionitrile to give N'-hydroxy-3-(methylamino)propanimidamide: A solution of 3-methylaminopropionitrile (1 g, 11.9 mmol) and hydroxylamine (50% in water, 0.8 cm3, 0.864 g, 13.1 mmol, 1.1 eq) in EtOH (1 cm³) was stirred at 30-50° C. for 3 hours and then at room temperature overnight. The solvent was removed under reduced pressure (rotary evaporator followed by high vacuum line) to give the product N'-hydroxy-3-(methylamino)propanimidamide (1.387 g, 99.5%) as a thick pale yellow oil.

References:

US2009/112024,2009,A1 Location in patent:Page/Page column 22