PROPYLSULFAMOYL CHLORIDE synthesis
- Product Name:PROPYLSULFAMOYL CHLORIDE
- CAS Number:10305-42-7
- Molecular formula:C3H8ClNO2S
- Molecular Weight:157.62
107-10-8
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10305-42-7
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$48.00/100mg
Yield:10305-42-7 155 g
Reaction Conditions:
with sulfuryl dichloride;triethylamine in dichloromethane at -10 - 10; for 4 h;Inert atmosphere;Reagent/catalyst;Temperature;
Steps:
1.1 (1) Synthesis of n-propylamine sulfonyl chloride
Under a nitrogen atmosphere, 135 g of the compound of formula I (1 mol) was charged into a clean four-necked reaction flask, 250 ml of dichloromethane was added,The mixture was cooled to -10 ° C, and a mixture of 59.1 g (1 mol) of compound of formula II and 101.2 g of triethylamine was slowly added dropwise to control the dropping time for about 60 minutes,Drop finished,The temperature was stirred at 10 ° C for about 3 hours. The reaction was concentrated under reduced pressure to give 155 g of the compound of formula III which was used directly in the next step.
References:
CN107141238,2017,A Location in patent:Paragraph 0026; 0027; 0028; 0033-0035; 0040-0042; 0047-0049
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10305-42-7
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