pyrazin-2(1H)-one, sodium salt synthesis

Yield:24387-68-6 71%

Reaction Conditions:

with sodium hydride at 0 - 20; for 2 h;Reagent/catalyst;

Steps:

1.b; 2-3

(b) The liquid obtained by distillation in the above three-necked flask is cooled to 0°C while adding0.1mol sodium hydride and 0.125mol glyoxal (40%) solution, incubate for 1h,Naturally warm to room temperature and continue to hold the reaction for 1h. After the reaction is over,The reaction solution was concentrated to a viscous state by distillation under reduced pressure, and crystallized with stirring at 0°C.Centrifugation and drying yielded 4.19g of 2-hydroxypyrazine sodium with a yield of 71%.

References:

CN111004187,2020,A Location in patent:Paragraph 0034; 0036-0037; 0041-0046