Pyrazine, 1-piperazinyl-, monohydrochloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride in diethyl ether at 20; for 1 h;

Steps:

2

Preparation of compound 47: A solution of compound 46 (250 mg) in ether/HCl (30 ml) was stirred at room temperature for 1 h and monitored by TLC. After 1 h, the reaction mixture was concentrated under reduced pressure to yield compound 47 (200 mg, 98% yield) which was washed with hexane and used without further purification.

References:

US2010/331307,2010,A1 Location in patent:Page/Page column 28