Pyrazolo[1,5-a]-1,3,5-triazine-2,4(1H,3H)-dione synthesis

Yield:34683-40-4 64%

Reaction Conditions:

with sodium ethanolate in ethanol; for 0.5 h;Reflux;

Steps:

4.6. General procedure for the preparation of 1,3-dihydro-pyrazolo[1,5-a][1,3,5]triazin-2,4-diones (10, 13)

General procedure: 1 mmol of the corresponding N-ethoxycarbonyl-N'-(pyrazol-3-yl) urea was refluxed in a mixture of 4 ml of ethanol and 0.76 ml of 21%wt EtONa (2 mmol) ethanol solution for 0.5 h. The precipitate that formed was collected by filtration, then dissolved in water and acidified with HCI until pH 4. The precipitate formed was filtered and recrystallized from methanol/water.

References:

Sun, Lingyi;Bera, Hriday;Chui, Wai Keung [European Journal of Medicinal Chemistry,2013,vol. 65,p. 1 - 11]