ChemicalBook CAS DataBase List Pyridine, 2-bromo-5-(dimethoxymethyl)-

Pyridine, 2-bromo-5-(dimethoxymethyl)- synthesis

4synthesis methods

Product Name:Pyridine, 2-bromo-5-(dimethoxymethyl)-
CAS Number:174608-37-8
Molecular formula:C8H10BrNO2
Molecular Weight:232.07

67-56-1 Synthesis

67-56-1
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149806-06-4 Synthesis

149806-06-4
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174608-37-8
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Yield:174608-37-8 99%

Reaction Conditions:

with toluene-4-sulfonic acid;trimethyl orthoformate at 20; for 24 h;

Steps:

69.A

Trimethyl orthoformate (643 μl, 5.9 mmol) and p-toluene sulphonic acid monohydrate (102 mg, 0.54 mmol) were added to 6-bromo-pyridine-3- carbaldehyde (1 g, 5.37 mmol) dissolved in MeOH (40 ml). The mixture was stirred for 24 h at room temperature and then partitioned between water and Et₂O. The organic extract was washed with water, 5% Na₂COs, dried over Na₂SO₄ and evaporated under vacuo to give 1.2 g of 2-bromo-5-dimethoxymethyl-pyridine as a brown oil. Yield = 99%

References:

WO2006/37761,2006,A1 Location in patent:Page/Page column 45

149806-06-4 Synthesis

149806-06-4
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$5.00/1g

149-73-5 Synthesis