![](/CAS/GIF/203569-23-7.gif)
Pyridine, 2-Methyl-6-(1H-pyrazol-3-yl)- synthesis
- Product Name:Pyridine, 2-Methyl-6-(1H-pyrazol-3-yl)-
- CAS Number:203569-23-7
- Molecular formula:C9H9N3
- Molecular Weight:159.19
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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![Pyridine, 2-Methyl-6-(1H-pyrazol-3-yl)-](/CAS/GIF/203569-23-7.gif)
203569-23-7
27 suppliers
$139.00/100mg
Yield: 90%
Reaction Conditions:
with hydrazine hydrate in ethanol at 25; for 20 h;Inert atmosphere;
Steps:
4-2A.2 Step 2: Preparation of 2-methyl-6-(1H-pyrazol-3-yl)pyridine
To a solution of (E)-3-(dimethylamino)-1-(6-methylpyridin-2-yl)prop-2-en-1-one (190.0 mg, 1.0 mmol, 1.0 equiv.) in ethanol (5.0 mL) with an inert atmosphere of nitrogen, was added hydrazine hydrate (2.0 mL). The resulting solution was stirred for 20 h at 25oC and concentrated under reduced pressure. The crude product was purified by Flash-Prep-HPLC with the following conditions (IntelFlash-1): Column, C18 silica gel; mobile phase, water and acetonitrile (10.0% acetonitrile up to 100.0% in 20 min); Detector, UV 254 nm. 150 mg (90%) of 2-methyl-6-(1H- pyrazol-3-yl)pyridine was obtained as a yellow solid. MS m/z [M+H]+ (ESI):160
References:
SILVERBACK THERAPEUTICS, INC. WO2021/72330, 2021, A1 Location in patent:Page/Page column 303-304
![2-Bromo-6-methylpyridine](/CAS/GIF/5315-25-3.gif)
5315-25-3
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$6.00/5g
![Pyridine, 2-Methyl-6-(1H-pyrazol-3-yl)-](/CAS/GIF/203569-23-7.gif)
203569-23-7
27 suppliers
$139.00/100mg
![1-(6-METHYL-PYRIDIN-2-YL)-ETHANONE](/CAS/GIF/6940-57-4.gif)
6940-57-4
163 suppliers
$12.00/250mg
![Pyridine, 2-Methyl-6-(1H-pyrazol-3-yl)-](/CAS/GIF/203569-23-7.gif)
203569-23-7
27 suppliers
$139.00/100mg
![2-Propen-1-one, 3-(dimethylamino)-1-(6-methyl-2-pyridinyl)-](/CAS/20200611/GIF/79571-43-0.gif)
79571-43-0
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![Pyridine, 2-Methyl-6-(1H-pyrazol-3-yl)-](/CAS/GIF/203569-23-7.gif)
203569-23-7
27 suppliers
$139.00/100mg
![2-Acetylpyridine](/CAS/GIF/1122-62-9.gif)
1122-62-9
543 suppliers
$7.00/10g
![Pyridine, 2-Methyl-6-(1H-pyrazol-3-yl)-](/CAS/GIF/203569-23-7.gif)
203569-23-7
27 suppliers
$139.00/100mg