Pyridine, 3-bromo-4-(3-bromopropyl)- synthesis

3synthesis methods

Product Name:Pyridine, 3-bromo-4-(3-bromopropyl)-
CAS Number:216012-95-2
Molecular formula:C8H9Br2N
Molecular Weight:278.97

229184-01-4
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216012-95-2
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Yield:216012-95-2 72%

Reaction Conditions:

with carbon tetrabromide;triphenylphosphine in dichloromethane at 0 - 20; for 0.5 h;

Steps:

192.4 Step 4: Synthesis of 3-bromo-4-(3-bromopropyl)pyridine

To a solution of 3-(3-bromo-4-pyridyl)propan-1-ol (1.95 g, 9.0 mmol) in dichloromethane (50 mL) was added triphenylphosphine (3.55 g, 13.5 mmol) at room temperature, followed by addition of carbon tetrabromide (4.49 g, 13.5 mmol) at 0 °C. After stirring at room temperature for 0.5 hour, the reaction mixture was concentrated under reduced pressure. Purification via silica gel column chromatography (ethyl acetate/petroleum ether) afforded the title compound as a light-yellow oil. Yield: 2.10 g, 72%. LCMS (ESI) m/z: 280.0 (M+H).¹H NMR (DMSO-d6, 300 MHz): δ 8.67 (s, 1H), 8.46 (d, 1H, J=5.1 Hz), 7.40 (d, 1H, J=5.1 Hz), 3.58 (t, 2H, J=6.6 Hz), 2.72-2.91 (m, 2H), 2.03-2.17 (m, 2H).

References:

WO2022/109492,2022,A1 Location in patent:Page/Page column 552-554

70201-43-3 Synthesis

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216012-95-2
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References

3-Bomo-4-pridinepropanoic acidethylester

463303-98-2
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References