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98420-89-4

Pyridine, 4-chloro-2-ethenyl- (9CI) synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: 99 percent / aq. hydrogen peroxide / acetic acid / Heating
2.1: 75.3 percent / HNO3; H2SO4 / 100 °C
3.1: 85 percent / HCl / H2O / 160 °C
4.1: Ac2O / 4 h / 110 °C
4.2: 54 percent / HCl / H2O / 2 h / 80 °C
5.1: 58 percent / H2SO4 / 90 °C

References:

Zhang, Christiana Xin;Liang, Hong-Chang;Kim, Eun-il;Shearer, Jason;Helton, Matthew E.;Kim, Eunsuk;Kaderli, Susan;Incarvito, Christopher D.;Zuberbuehler, Andreas D.;Rheingold, Arnold L.;Karlin, Kenneth D. [Journal of the American Chemical Society,2003,vol. 125,# 3,p. 634 - 635]