![](/CAS/GIF/215437-47-1.gif)
PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)- synthesis
- Product Name:PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)-
- CAS Number:215437-47-1
- Molecular formula:C12H10ClNO
- Molecular Weight:219.67
![2,5-Dichloropyridine](/CAS/GIF/16110-09-1.gif)
16110-09-1
453 suppliers
$5.00/1g
![Benzyl alcohol](/CAS/GIF/100-51-6.gif)
100-51-6
1384 suppliers
$5.00/100g
![PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)-](/CAS/GIF/215437-47-1.gif)
215437-47-1
21 suppliers
inquiry
Yield:215437-47-1 91%
Reaction Conditions:
Stage #1: 2,5 dichloropyridine in N,N-dimethyl-formamide at 0; for 0.5 h;Inert atmosphere;
Stage #2: benzyl alcohol in N,N-dimethyl-formamide at 5;Inert atmosphere;
Steps:
129.1 Step 1 :
To a solution of 2,5-dichloropyridine (2 g, 13.51 mmol, 1.0 eq) in DMF (30 mL) under nitrogen atmosphere at 0 °C was added sodium hydride (0.65 g, 16.21 mmol, 1.2 eq) in portions. The mixture was stirred for 0.5 h and followed by addition of a solution of BnOH (1.75 g, 16.21 mmol, 1.2 eq) in DMF (2 mL). Then the resulting mixture was stirred at 5 °C overnight before it was diluted with water (90 mL) and extracted with EtOAc (3 x 90 mL). The combined organic layer was washed with brine, dried over NaiSCL, and concentrated. The crude residue was purified by flash column chromatography on silica gel (petroleum ether:EtOAc=100: l) to give 2-(benzyloxy)-5-chloropyridine (2.7 g, 91% yield).
References:
WO2020/186220,2020,A1 Location in patent:Paragraph 0293
![5-CHLORO-2-HYDROXYPYRIDINE](/CAS/GIF/4214-79-3.gif)
4214-79-3
240 suppliers
$6.00/1g
![Benzyl chloride](/CAS/GIF/100-44-7.gif)
100-44-7
627 suppliers
$13.50/250G
![PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)-](/CAS/GIF/215437-47-1.gif)
215437-47-1
21 suppliers
inquiry
![Benzyl alcohol](/CAS/GIF/100-51-6.gif)
100-51-6
1384 suppliers
$5.00/100g
![PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)-](/CAS/GIF/215437-47-1.gif)
215437-47-1
21 suppliers
inquiry