pyrido[2,3-d]pyridazin-8(7H)-one synthesis

5synthesis methods

Product Name:pyrido[2,3-d]pyridazin-8(7H)-one
CAS Number:15375-79-8
Molecular formula:C7H5N3O
Molecular Weight:147.13

1029720-23-7
34 suppliers
$41.00/100mg

15375-79-8
19 suppliers
$220.00/100mg

Yield:15375-79-8 95%

Reaction Conditions:

with hydrazine hydrate in methanol; for 5 h;Reflux;

Steps:

4.7 General procedure for the preparation of 5-8

General procedure: A solution of 25-28 (3.08g, 0.01mol) and hydrazine hydrate (2.00g, 0.04mol) in methanol (50mL) was stirred under reflux for 5h. The solvent was evaporated under reduced pressure, and the residue was recrystallized from MeOH-H₂O (9:1).

References:

Yaremenko, Anatoliy G.;Volochnyuk, Dmitriy M.;Shelyakin, Vyacheslav V.;Grygorenko, Oleksandr O. [Tetrahedron,2013,vol. 69,# 33,p. 6799 - 6803]