PYRIMIDIN-2-YLBORONIC ACID synthesis
- Product Name:PYRIMIDIN-2-YLBORONIC ACID
- CAS Number:851199-85-4
- Molecular formula:C4H5BN2O2
- Molecular Weight:123.91
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Yield:-
Reaction Conditions:
Stage #1:2-bromopyrimidine with n-butyllithium in diethyl ether at -78; for 1 h;Inert atmosphere;
Stage #2:Trimethyl borate in diethyl ether at -78; for 0.5 h;Inert atmosphere;
Stage #3:water with hydrogenchloride in diethyl ether at 20; for 12 h;Inert atmosphere;
Steps:
5.1
In a N2 gas purification system, compound I and BuLi (1.5 equivalents) were added to diethyl ether, and the mixture was stirred at a temperature of -78 ° C. After the mixture was reacted for 1 hour, trimethyl borate (1.2 equivalents) was added, and the mixture was stirred at a temperature of -78 ° C for 30 minutes. The mixture was reacted at room temperature for 12 hours. Aqueous HCl in DI (30 ml) was added and the organic solvent was removed. The residue was filtered to obtain compound J as a white solid.
References:
Lejin Display Co., Ltd.;Lu Xiaozhen;Yin Guichen;Xu Fumin CN110590755, 2019, A Location in patent:Paragraph 0129-0133