Pyrimidine, 4,5-dimethoxy- (9CI) synthesis
- Product Name:Pyrimidine, 4,5-dimethoxy- (9CI)
- CAS Number:71133-26-1
- Molecular formula:C6H8N2O2
- Molecular Weight:140.14
5193-88-4
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$29.00/100mg
71133-26-1
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$22.00/100mg
Yield:71133-26-1 99%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in methanol at 20; under 760.051 Torr; for 3 h;
Steps:
1.1 Step 1: Synthesis of 4,5-dimethoxypyrimidine, 2
A solution of 4-chloro-5,6-dimethoxypyrimidine, 1 (5g, 28.64 mmol) in dry methanol (100 mL) was hydrogenated at 1 atm H2 gas pressure using Pd (10%) on carbon (1 g) as catalyst for 3 hours. After completion of the reaction, the reaction mixture was filtered through celite pad and concentrated to dryness to get (4 g, 99 %) of pure 4,5-dimethoxypyrimidine, 2, as a white solid. UPLC = Calculated for C6H8N202 140.14, Observed = 141.1
References:
WO2017/83431,2017,A2 Location in patent:Paragraph 00233; 00234; 00246
695-87-4
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$60.00/100mg
71133-26-1
24 suppliers
$22.00/100mg