Pyrimidine, 4-chloro-5-methoxy-2-(methylsulfonyl)- synthesis
- Product Name:Pyrimidine, 4-chloro-5-methoxy-2-(methylsulfonyl)-
- CAS Number:31464-64-9
- Molecular formula:C6H7ClN2O3S
- Molecular Weight:222.65
87026-45-7
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31464-64-9
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Yield:31464-64-9 100%
Reaction Conditions:
with m-chloroperoxybenzoic acid in methanol;water;4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;
Steps:
4-Chloro-2-methanesulfonyl-5-methoxy-pyrimidine
4-Chloro-2-methanesulfonyl-5-methoxy-pyrimidine A solution of 3-chloroperoxybenzoic acid (0.4 g, 2.3 mmol) in DCM (2 ml) was added dropwise to a solution of 4-chloro-5-methoxy-2-methylsulfanyl-pyrimidine (0.15 g, 0.78 mmol) in DCM (10 ml) and the mixture was stirred at room temperature for 12 h. Water (10 ml) was added, the aqueous phase was extracted with DCM and concentrated in vacuo. The crude residue was purified by column chromatography with DCM/1% NH3 in MeOH (98:2) as the eluent to give the title compound (0.18 g, 100%).
References:
US2012/202806,2012,A1
1671-08-5
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