Pyrimidine, 5-bromo-4-hydrazinyl-2-(methylthio)- synthesis

Yield:875-96-7 99.9%

Reaction Conditions:

with hydrazine hydrate in ethanol; for 4 h;

Steps:

1 Step 1. Synthesis of compound M1-2

Add substrate to dry 250ml single neck vial5-Bromo-4-chloro-2-methylsulfonyl-pyrimidine (1 g, 4.38 mmol) was added with ethanol (20 ml) to dissolve, and N2H4 H2O (440 mg, 9.21 mmol) was slowly added dropwise with stirring to stir the reaction for 4 hours.LC-MS monitoring.After the reaction was completed, it was extracted with water and ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography.The product M1-1(5-bromo-2-methylsulfonyl-pyrimidin-4-yl)hydrazine was obtained(1.03g, 99.9%)

References:

CN114426541,2022,A Location in patent:Paragraph 0068-0071