Quinoxaline, 2-(chloromethyl)- synthesis

8synthesis methods

Product Name:Quinoxaline, 2-(chloromethyl)-
CAS Number:106435-53-4
Molecular formula:C9H7ClN2
Molecular Weight:178.62

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Yield: 87%

Reaction Conditions:

with tetra-(n-butyl)ammonium iodide;1,2-dichloro-ethane;urea at 110; for 0.5 h;Microwave irradiation;

Steps:

General procedure for chlorination of 2-methylquinolines:
General procedure: 2-Methylquinolines 1(2 mmol), TBAI (2 mmol), urea (2 mmol), and 1,2-dichloroethane (10 mL) weremixed in a microwave tube. The reaction mixture was stirred at 110 °C for 30 min under microwave irradiation using a CEM Discover microwave reactor(the highest power: 150 W; run time: 5 min; hold time: 30 min; temperature:110 °C). The resulting reaction mixture was concentrated in vacuo, and the crude residue was purified by flash chromatography on silica gel using hexane/EtOAc as eluent.

References:

Xie, Yuanyuan;Li, Lehuan [Tetrahedron Letters,2014,vol. 55,# 29,p. 3892 - 3895] Location in patent:supporting information

7251-61-8
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$20.00/5g