(R)-1,2-EPOXYPENTANE synthesis

Yield: 77%

Reaction Conditions:

with potassium hydroxide at -70;

Steps:

4.5.1.3 (R)-2-Isopropyloxirane [(R)-78]
General procedure: To 11.2g (91.3mmol) of (S)-77 chilled to -70°C was added 10.25g (183mmol) of finely ground potassium hydroxide. The slurry was allowed to warm to rt, then distilled (bp 71-73°C) giving 4.79g (61%) of (R)-78.

References:

Plazinska, Anita;Pajak, Karolina;Rutkowska, Ewelina;Jimenez, Lucita;Kozocas, Joseph;Koolpe, Gary;Tanga, Mary;Toll, Lawrence;Wainer, Irving W.;Jozwiak, Krzysztof [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 1,p. 234 - 246]