(R)-1-cyclopentyl-1-phenylethane-1,2-diol synthesis

8synthesis methods

Product Name:(R)-1-cyclopentyl-1-phenylethane-1,2-diol
CAS Number:183201-49-2
Molecular formula:C13H18O2
Molecular Weight:206.28

64471-45-0
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(R)-1-cyclopentyl-1-phenylethane-1,2-diol

183201-49-2
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Yield:183201-49-2 100%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran; for 3 h;Reflux;

Steps:

1.5 1.5 Synthesis of (R) -a-phenyl-α-cyclopentyl-α-phenylmethyl p-toluenesulfonate (VIII)

(R) -a-phenyl-a-cyclopentyl-a-hydroxyacetic acid (VI) in an amount of 2.2 g (0. Olmol)In 10 mL of anhydrous THF was slowly added dropwise to a 20 mL anhydrous THF solution containing LiAlH4 (0.02 mol), and the temperature was slowly raised with stirringTo reflux, reaction 3h. After cooling, carefully add 2 mL of saturated NaHC03 solution and add 10 mL of 2N NaOH solution. IsolationThe aqueous phase was extracted with diethyl ether. The combined organic phases were washed with saturated brine and dried over anhydrous sodium sulfate. Vacuum distillation,The solvent was removed to give 2.06 g of (R) -a-phenyl-α-cyclopentyl-α-hydroxyethanol (VII) as colorless needles,100%,

References:

CN102070631,2016,B Location in patent:Paragraph 0085-0086

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185030-09-5
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183201-49-2
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References

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183201-49-2
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References

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183201-49-2
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References

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References