(R)-1-Morpholinopropan-2-aMine hydrochloride synthesis

Yield:1161931-61-8 86%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;dichloromethane at 0 - 20; for 2 h;

Steps:

17

PREPARATION 17 (R)-1-Methyl-2-morpholin-4-yl-ethylaminehydrochloride Add 1.6 M hydrogen chloride in dioxane (120 mL) to a solution of (R)-(1-methyl-2-morpholin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.05 mol, 12 g) in dry dichloromethane (75 mL) at 0° C. Warm the reaction mixture to room temperature and stir for 2 h. Filter the precipitate and dry under vacuum to obtain the title compound (9.2 g, 86%) as a white solid. ¹H NMR (400 MHz, DMSO-d₆) δ 1.29 (d, 3H), 3.10 (br s, 2H), 3.38 (br s, 4H), 3.79 (br s, 5H).

References:

US2009/163472,2009,A1 Location in patent:Page/Page column 20