![](/CAS/20150408/GIF/1161931-61-8.gif)
(R)-1-Morpholinopropan-2-aMine hydrochloride synthesis
- Product Name:(R)-1-Morpholinopropan-2-aMine hydrochloride
- CAS Number:1161931-61-8
- Molecular formula:C7H17ClN2O
- Molecular Weight:180.6757
![Carbamic acid, N-[(1R)-1-methyl-2-(4-morpholinyl)ethyl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/1000587-55-2.gif)
1000587-55-2
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![(R)-1-Morpholinopropan-2-aMine hydrochloride](/CAS/20150408/GIF/1161931-61-8.gif)
1161931-61-8
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Yield:1161931-61-8 86%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;dichloromethane at 0 - 20; for 2 h;
Steps:
17
PREPARATION 17 (R)-1-Methyl-2-morpholin-4-yl-ethylaminehydrochloride Add 1.6 M hydrogen chloride in dioxane (120 mL) to a solution of (R)-(1-methyl-2-morpholin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.05 mol, 12 g) in dry dichloromethane (75 mL) at 0° C. Warm the reaction mixture to room temperature and stir for 2 h. Filter the precipitate and dry under vacuum to obtain the title compound (9.2 g, 86%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 1.29 (d, 3H), 3.10 (br s, 2H), 3.38 (br s, 4H), 3.79 (br s, 5H).
References:
US2009/163472,2009,A1 Location in patent:Page/Page column 20